Acetaminophen, aspirin, and ibuprofen are three common pain relievers available over-the-counter (OTC). Aspirin is the oldest pain reliver and belongs to a class of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is also an NSAID. Acetaminophen, which causes less stomach irritation, is a non-aspirin pain reliver. All three have benefits and uses that make them unique, but the problems with their use are just as diverse. In this section, learn about acetaminophen safety with children, which includes fast facts about the medicine. You will also find information on a national Know Your Dose website that stresses the importance of recognizing acetaminophen as an ingredient in more than 600 different prescription and OTC medicines. Another section discusses aspirin and aspirin containing products, which includes a list of safety tips to follow when using these products. And, also learn more about the heart risks associated with nonsteroidal anti-inflammatory medicines.