Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with an increased risk of heart attack and stroke (except low-dose [81 mg] aspirin). Over-the-counter (OTC) NSAIDs include aspirin, naproxen (Aleve, Naprosyn, Anaprox, others), and ibuprofen (Motrin, Advil, Nuprin, others). According to the US Food and Drug Administration (FDA), studies show using NSAIDS can increase the risk of heart attack or stroke in patients with or without heart disease or risk factors for heart disease. However, in general, patients with a known history of (or risk factors for) heart disease have a higher likelihood of heart attack or stroke following NSAID use than other patients. All NSAIDS may have a similar risk, and the risk appears to be greater at higher doses and increases with the longer use of the NSAID. If you have a history or risk of heart disease, always speak with your doctor before starting an NSAID.
Patients should keep in mind that many combination medicines contain NSAIDs, including those used for colds and flu, so it is important to read the labels and Drug Facts labels before using any OTC medicine. If you are using an NSAID and experience symptoms such as chest pain, trouble breathing, sudden weakness or numbness in your body, or sudden slurred speech, immediately seek medical attention.
Reference
1) US Food and Drug Administration (FDA). FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. Published July 9. 2015. Updated February 26, 2018.
