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Reporting a Medication Error

Muscle Problems with Cholesterol Medicines

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Republished November 1, 2024

Cholesterol-lowering medicines can cause a variety of muscle problems. These side effects can range from mild soreness to a potentially deadly condition called rhabdomyolysis (pronounced rab-doe-my-o-ly-sis).

Rhabdomyolysis is a breakdown of muscle fibers in the body. The damaged muscles release harmful by-products that clog the kidneys, causing kidney failure.

The risk of rhabdomyolysis is greater when patients take more than 20 mg daily of simvastatin (Zocor) along with another medicine, amiodarone. Simvastatin is a common cholesterol-lowering medicine, and amiodarone is a heart medicine used to control irregular beats.

Combination medicines that contain simvastatin, such as Vytorin (ezetimibe and simvastatin), can also lead to this problem. Many cholesterol-lowering medicines taken with other drugs can also increase the risk of rhabdomyolysis, such as:

  • Medicines used to lower triglyceride levels, such as Lopid (gemfibrozil)
  • Medicines used to treat fungal infections, such as Diflucan (fluconazole) and Sporanox (itraconazole)
  • Certain antibiotics, such as clarithromycin and erythromycin

If you or family members take simvastatin and other medicines listed, call your doctor if you develop symptoms of rhabdomyolysis such as pain, muscle cramps, tenderness, stiffness, and muscle spasms.

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